rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1997-2-6
|
pubmed:abstractText |
Glutaredoxin is a small protein (12 kDa) catalyzing glutathione-dependent disulfide oxidoreduction reactions in a coupled system with NADPH, GSH, and glutathione reductase. A cDNA encoding the human glutaredoxin gene (HGMW-approved symbol GLRX) has recently been isolated and cloned from a human fetal spleen cDNA library. The screening of a human genomic library in Charon 4A led to the identification of three genomic clones. Using fluorescence in situ hybridization to metaphase chromosomes with one genomic clone as a probe, the human glutaredoxin gene was localized to chromosomal region 5q14. This localization at chromosome 5 was in agreement with the somatic cell hybrid analysis, using DNA from a human-hamster and a human-mouse hybrid panel and using a human glutaredoxin cDNA as a probe.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0888-7543
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
32
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
455-7
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8838810-Animals,
pubmed-meshheading:8838810-Chromosome Mapping,
pubmed-meshheading:8838810-Chromosomes, Human, Pair 5,
pubmed-meshheading:8838810-Cricetinae,
pubmed-meshheading:8838810-DNA,
pubmed-meshheading:8838810-DNA, Complementary,
pubmed-meshheading:8838810-Genes,
pubmed-meshheading:8838810-Glutaredoxins,
pubmed-meshheading:8838810-Humans,
pubmed-meshheading:8838810-Hybrid Cells,
pubmed-meshheading:8838810-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8838810-Mice,
pubmed-meshheading:8838810-Oxidoreductases,
pubmed-meshheading:8838810-Proteins
|
pubmed:year |
1996
|
pubmed:articleTitle |
The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14.
|
pubmed:affiliation |
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. bb1papec/lucano.uco.es
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|