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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-12-12
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pubmed:abstractText |
Integrin-adressin binding is a critical step in lymphocyte attachment to target tissues. The lymphocyte function associated antigen (LFA-1)/intercellular adhesion molecule-1 (ICAM-1) pathway has been shown to be involved in the homing of lymphocytes to arthritic joints in animal models. The mucosal recognition system [alpha E beta 7/E-cadherin, alpha 4 beta 7/mucosal vascular adressin cellular adhesion molecule 1 (MADCAM-1)] has been implicated in the autoimmune process of nonobese diabetic mice and in rheumatoid arthritis (RA). We developed a model for in vivo study of radiolabelled lymphocyte circulation and attachment to human engrafted rheumatoid synovium, and studied the involvement of LFA-1 and alpha E beta 7 integrin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8838505-Animals,
pubmed-meshheading:8838505-Antigens, CD,
pubmed-meshheading:8838505-Antigens, CD18,
pubmed-meshheading:8838505-Arthritis, Rheumatoid,
pubmed-meshheading:8838505-Cell Adhesion,
pubmed-meshheading:8838505-Cell Movement,
pubmed-meshheading:8838505-Disease Models, Animal,
pubmed-meshheading:8838505-Female,
pubmed-meshheading:8838505-Humans,
pubmed-meshheading:8838505-Integrin beta Chains,
pubmed-meshheading:8838505-Integrins,
pubmed-meshheading:8838505-Lymphocytes,
pubmed-meshheading:8838505-Male,
pubmed-meshheading:8838505-Mice,
pubmed-meshheading:8838505-Mice, SCID,
pubmed-meshheading:8838505-Osteoarthritis,
pubmed-meshheading:8838505-Synovial Membrane
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pubmed:year |
1996
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pubmed:articleTitle |
In vivo migration of radiolabelled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of beta 2 and beta 7-integrin.
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pubmed:affiliation |
Service d'Immuno-Rhumatologie, Centre Gui-de-Chauliac, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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