Linked Life Data

8837142

Source:http://linkedlifedata.com/resource/pubmed/id/8837142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-12-20
pubmed:abstractText
Oral mucositis is a common problem after high-dose methotrexate (HD-MTX) treatment. Our purpose was to identify factors associated with the development of mucositis in children with ALL who had no delayed elimination of methotrexate (MTX) according to the conventional criteria (p-MTX at 42 hours < 1 mumol/L and at 66 hours < 0.2 mumol/L). Pharmacokinetic studies of MTX and the metabolite 7-hydroxymethotrexate (7-OHMTX) in plasma and saliva were carried out in 13 children treated with HD-MTX (5-8 g/m2 intravenously over 24 hours for a total of 44 courses). Oral mucositis was evaluated according to the criteria of the World Health Organization. Mucositis was observed in 52% of the infusions. In 28 infusions with no delayed elimination of MTX 39% developed mucositis, which was found to correlate significantly with low systemic clearance of MTX during the infusion and a low p-7-OHMTX/p-MTX ratio at 66 hours after the start of infusion. The MTX concentration in saliva did not show any correlation with the development of mucositis. The present conventional criteria for high-risk MTX concentrations might need to be reevaluated because a high percentage of patients still suffer from oral toxicity despite "normal" elimination. A reduced ratio between the simultaneous concentrations of 7-OHMTX and MTX in plasma may be a possible mechanism of this "unpredictable" oral toxicity.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0888-0018
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-67
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Oral mucositis in children with acute lymphoblastic leukemia after high-dose methotrexate treatment without delayed elimination of methotrexate: relation to pharmacokinetic parameters of methotrexate.
pubmed:affiliation
Department of Paediatrics, University Hospital of Aarhus, Denmark.
pubmed:publicationType
Journal Article, Comment, Research Support, Non-U.S. Gov't