Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2 Suppl
|
| pubmed:dateCreated |
1996-12-12
|
| pubmed:abstractText |
Today's knowledge on the natural history of hepatitis C virus infection derives mainly from local outbreaks and still limited clinical trials. There is a general consensus now that chronic infection occurs in at least 80% of cases after acute disease. Chronic hepatitis C usually runs a mild course with little or no morbidity. In a 15-yr follow-up evaluation of a cohort of 152 women having been infected with HCV-contaminated Rho (D)-immunoglobulin none had developed chronic active hepatitis or cirrhosis. On the other hand, half of 80 patients who started out with more advanced forms of chronic hepatitis C developed cirrhosis over a mean period of 12 yr. Recent observations indicate that progression to severe chronic hepatitis may even occur in HCV-RNA positive individuals with normal aminotransferase activities in serum for long periods. Overall, chronic HCV infection is a slowly progressive disease which often needs histological evaluation, especially in patients with normal biochemical findings.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0168-8278
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
52-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1996
|
| pubmed:articleTitle |
The natural history of hepatitis C: clinical experiences.
|
| pubmed:affiliation |
Medizinische Klinik, Krankenhaus Siegburg, Germany.
|
| pubmed:publicationType |
Journal Article
|