Linked Life Data

8836343

Source:http://linkedlifedata.com/resource/pubmed/id/8836343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-2-4
pubmed:abstractText
The aim of this study was to investigate whether patients with food allergy had a cytokine imbalance of interleukin (IL)-4 and interferon-gamma (IFN-gamma) production. Diagnostic procedures including skin prick tests, determination of food-specific serum IgEs, and positive double-blind, placebo-controlled, food challenges identified 15 adult patients. They were compared with 15 age- and sex-matched healthy subjects. Peripheral blood mononuclear cells (PBMC) were incubated for 24, 48, and 72 h in the presence of phytohemagglutinin plus phorbol myristate acetate. After mitogen stimulation, culture supernatants from patients with food allergy contained significantly less IFN-gamma but increased IL-4 when compared with healthy controls. Secretion of IL-4 was maximal at 24 h and IFN-gamma secretion was maximal at 72 h. There was no correlation between cytokine secretion in vitro and serum IgE level. These findings demonstrated that an imbalance of IL-4 and IFN-gamma production is present in food allergy, as documented in other allergic diseases, but other mechanisms are probably also involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0105-4538
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
350-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Interleukin-4 and interferon-gamma production by peripheral blood mononuclear cells from food-allergic patients.
pubmed:affiliation
Laboratoire d'Immunopathologie Digestive, INSERM, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
pubmed:publicationType
Journal Article, Comparative Study