Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-12-17
|
| pubmed:abstractText |
With the intent of increasing the signal-to-noise ratio (SNR) of fluorine magnetic resonance imaging and enabling new applications, we have developed a novel class of agents based on protein encapsulation of fluorocarbons. Microspheres formed by high-intensity ultrasound have a gaussian size distribution with an average diameter of 2.5 microns. As with conventional emulsions, these microspheres target the reticuloendothelial system. However, our sonochemically produced microspheres, because of a high encapsulation efficiency, show increases in the SNR of up to 300% compared to commercially available emulsions. We also demonstrate an increase in the circulation lifetime of the microspheres with the bloodstream by more than 30-fold with a chemical modification of the outer surface of the microsphere. Finally, by encapsulating mixtures of fluorocarbons that undergo solid/liquid phase transitions, we can map temperature in the reticuloendothelial system, with signal changes of approximately 20-fold over a 5 degrees C range.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1053-1807
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
675-83
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8835962-Animals,
pubmed-meshheading:8835962-Body Temperature,
pubmed-meshheading:8835962-Chemistry, Physical,
pubmed-meshheading:8835962-Contrast Media,
pubmed-meshheading:8835962-Emulsions,
pubmed-meshheading:8835962-Female,
pubmed-meshheading:8835962-Fluorocarbons,
pubmed-meshheading:8835962-Half-Life,
pubmed-meshheading:8835962-Image Enhancement,
pubmed-meshheading:8835962-Magnetic Resonance Imaging,
pubmed-meshheading:8835962-Microspheres,
pubmed-meshheading:8835962-Mononuclear Phagocyte System,
pubmed-meshheading:8835962-Particle Size,
pubmed-meshheading:8835962-Physicochemical Phenomena,
pubmed-meshheading:8835962-Rats,
pubmed-meshheading:8835962-Rats, Inbred F344,
pubmed-meshheading:8835962-Serum Albumin, Bovine,
pubmed-meshheading:8835962-Surface Properties,
pubmed-meshheading:8835962-Tissue Distribution,
pubmed-meshheading:8835962-Ultrasonics
|
| pubmed:articleTitle |
Sonochemically produced fluorocarbon microspheres: a new class of magnetic resonance imaging agent.
|
| pubmed:affiliation |
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|