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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-12-10
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pubmed:abstractText |
The gene parC encodes the A subunit of topoisomerase IV of Escherichia coli. Mutations in the parC region analogous to those in the quinolone resistance-determining region of gyrA were investigated in 27 clinical isolates of E. coli for which ciprofloxacin MICs were 0.0007 to 128 micrograms/ml. Of 15 isolates for which ciprofloxacin MICs were > or = 1 microgram/ml, 8 showed a change in the serine residue at position 80 (Ser-80), 4 showed a change in Glu-84, and 3 showed changes in both amino acids. No mutations were detected in 12 clinical isolates for which ciprofloxacin MICs were < or = 0.25 micrograms/ml. These findings suggest that ParC from E. coli may be another target for quinolones and that mutations at residues Ser-80 and Glu-84 may contribute to decreased fluoroquinolone susceptibility.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1330320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1334483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1459936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1510409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1656869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1657531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1849888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-1850972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-186775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-200930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2168148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2170028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2548439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2655532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2658782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2679373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2828631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2830458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-2992360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3000292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3020376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3029692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3056253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-337300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3521490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-3532944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-6267993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-6323018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7486897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7492103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7625818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7830580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7840592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7872758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-7997176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-8104339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-8109921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-8227000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-8388197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8834907-8392306
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Ciprofloxacin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerase IV,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II alpha,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II beta,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8834907-Anti-Infective Agents,
pubmed-meshheading:8834907-Antigens, Neoplasm,
pubmed-meshheading:8834907-Base Sequence,
pubmed-meshheading:8834907-Ciprofloxacin,
pubmed-meshheading:8834907-DNA Topoisomerase IV,
pubmed-meshheading:8834907-DNA Topoisomerases, Type II,
pubmed-meshheading:8834907-DNA-Binding Proteins,
pubmed-meshheading:8834907-Drug Resistance, Microbial,
pubmed-meshheading:8834907-Escherichia coli,
pubmed-meshheading:8834907-Isoenzymes,
pubmed-meshheading:8834907-Molecular Sequence Data,
pubmed-meshheading:8834907-Mutation,
pubmed-meshheading:8834907-Sequence Homology, Amino Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.
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pubmed:affiliation |
Department of Microbiology, University of Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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