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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-12-4
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pubmed:abstractText |
We examined the association of nonsteroidal antiinflammatory drugs and breast cancer risk in a case-control study of 511 breast cancer patients and 1,534 population control subjects. The relative risk of breast cancer was reduced in women using these compounds at least 3 times per week for > or = 1 year [odds ratio (OR) = 0.66; 95% confidence interval (CI) = 0.52-0.83]. Odds ratios were similar for use of ibuprofen (0.57) or aspirin per se (0.69). Breast cancer risk declined with increasing exposure, and the greatest risk reduction (40%; odds ratio = 0.60; 95% CI = 0.40-0.91) occurred at the highest level of use (daily intake for > or = 5 years). These results indicate that nonsteroidal antiinflammatory drugs may have chemopreventive potential against the development of breast cancer.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1044-3983
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8834563-Adult,
pubmed-meshheading:8834563-Aged,
pubmed-meshheading:8834563-Aged, 80 and over,
pubmed-meshheading:8834563-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:8834563-Aspirin,
pubmed-meshheading:8834563-Breast Neoplasms,
pubmed-meshheading:8834563-Case-Control Studies,
pubmed-meshheading:8834563-Confidence Intervals,
pubmed-meshheading:8834563-Female,
pubmed-meshheading:8834563-Humans,
pubmed-meshheading:8834563-Ibuprofen,
pubmed-meshheading:8834563-Middle Aged,
pubmed-meshheading:8834563-Odds Ratio,
pubmed-meshheading:8834563-Ohio,
pubmed-meshheading:8834563-Risk
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pubmed:year |
1996
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pubmed:articleTitle |
Nonsteroidal antiinflammatory drugs and breast cancer.
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pubmed:affiliation |
Comprehensive Cancer Center, Ohio State University, Columbus, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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