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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-12-5
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pubmed:abstractText |
Cells capable of interferon (IFN)-gamma synthesis following mitogenic stimulation can be detected and quantified by a recently developed immunofluorescence assay and flow cytometric analysis. The production of IFN-gamma was investigated in a cohort of 20 asymptomatic human immunodeficiency virus (HIV)-seropositive patients with normal numbers of CD4+ lymphocytes, and in 10 healthy subjects. About 60% of asymptomatic stage A1 patients had increased percentages of blood lymphocytes capable of IFN-gamma synthesis, as compared to healthy subjects. The difference reflected the relatively higher numbers of CD8+ cells, in particular the CD8+ T cell subset lacking CD28 antigen expression. The strong correlation between the CD4+/CD8+ ratio and the CD8+CD28+/CD8+CD28- ratio suggests either a role for CD4+ cells in controlling the CD28+ phenotype or a role for CD8+CD28- cells in the decline of CD4+ lymphocytes. The peculiar ability of CD8+CD28- cells to produce high amounts of IFN-gamma, as compared to CD8+CD28+ cells, supports the hypothesis that the CD8+CD28- lymphocytes constitute a population that is functionally distinct from their double-positive counterparts.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0889-2229
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
20
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pubmed:volume |
12
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
135-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8834463-Antigens, CD28,
pubmed-meshheading:8834463-CD8-Positive T-Lymphocytes,
pubmed-meshheading:8834463-Flow Cytometry,
pubmed-meshheading:8834463-HIV Seropositivity,
pubmed-meshheading:8834463-HIV-1,
pubmed-meshheading:8834463-Humans,
pubmed-meshheading:8834463-Interferon-gamma,
pubmed-meshheading:8834463-Phenotype,
pubmed-meshheading:8834463-T-Lymphocyte Subsets,
pubmed-meshheading:8834463-Time Factors
|
pubmed:year |
1996
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pubmed:articleTitle |
Characterization of T cell subsets involved in the production of IFN-gamma in asymptomatic HIV-infected patients.
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pubmed:affiliation |
Institute of Microbiology, University of Brescia, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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