Linked Life Data

8833443

Source:http://linkedlifedata.com/resource/pubmed/id/8833443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-5-12
pubmed:abstractText
Cyclic nucleotide-gated (CNG) channels play important roles in both visual (Yau & Baylor 1989) and olfactory (Zufall et al 1994) signal transduction. The cloning of the gene coding for a rod photoreceptor channel (Kaupp et al 1989) and the subsequent cloning of related genes from olfactory neurons (Dhallan et al 1990, Ludwig et al 1990, Goulding et al 1992) has sparked much progress over the past several years in elucidating the structural bases for the function of the CNG channels. One of the surprising features to emerge from these cloning studies was that the CNG channels are structurally homologous to the voltage-gated channels (Jan & Jan 1990) despite the fact that the CNG channels are gated by the binding of a ligand-cAMP or cGMP-and not by voltage. In this review we focus on recent studies of the relationship between the structure and function of the CNG channels. Given the homology between CNG channels and voltage-gated channels, such studies are likely to provide important general information about the structure and function of a wide variety of channel types.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0147-006X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-63
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Structure and function of cyclic nucleotide-gated channels.
pubmed:affiliation
Department of Physiology and Biophysics, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195-7370, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't