Linked Life Data

8832575

Source:http://linkedlifedata.com/resource/pubmed/id/8832575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-24
pubmed:abstractText
The transcription of the rat alpha 2u globulin gene family is under complex hormonal control, involving the participation of glucocorticoids, estrogens, insulin, and growth hormone. The glucocorticoid induction of alpha 2u globulin is a secondary response; that is, ongoing protein synthesis is necessary for induction of alpha 2u globulin mRNA by the hormone. This secondary response is maintained when alpha 2u globulin genes are transfected into tissue culture cells which contain the glucocorticoid receptor. We have found that the glucocorticoid induction of alpha 2u globulin occurs only in permanent cell lines, in which the alpha 2u globulin genes are integrated into the host cell DNA; induction in transient transfections is minimal. Further, the DNA sequences required for alpha 2u globulin secondary response lie entirely in the 5' proximal promoter region; no intragenic sequence elements are required for, or participate in, the secondary response to glucocorticoids.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Sequence requirements for secondary glucocorticoid inducibility of rat alpha 2u globulin genes.
pubmed:affiliation
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston 29425, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.