Linked Life Data

8832484

Source:http://linkedlifedata.com/resource/pubmed/id/8832484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1996-11-27
pubmed:abstractText
We report on a time course study of cellular colonization of expanded polytetrafluoroethylene (ePTFE) membranes in rabbits. Bone defects (8 mm) were prepared with low speed burs in rabbit tibial metaphyses and covered with ePTFE membranes. The membranes were retrieved after 3, 6, 9, and 12 weeks. At 3 weeks, all membranes were filled by cells and osteoid tissue: no mineralized tissue was found. Osteoblasts positive for alkaline phosphatase (ALP) were observed on the outer surface and inside the material interstices of the membrane. At 6 weeks, it was possible to observe an increase of the quantity of the osteoid material inside the membranes. At 9 weeks, bone tissue was present and it usually originated from the most external part of the membrane, and spread to the central part of the membrane. Only the central portion of this bone appeared to be completely mineralized. A sharp decrease in the number of ALP-positive osteoblasts was observed. At 12 weeks, the quantity of bone present appeared to be substantially increased. Only a small percentage of the bone inside the membrane appeared to be completely mineralized. No cells positive to acid phosphatase were observed. These histological results confirm the high biocompatibility of ePTFE membranes and the bone formation inside the ePTFE interconnected nodes could, probably, help in achieving a good biomaterial-tissue integration with predictable results in bone regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3492
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
720-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Cellular colonization and bone formation into expanded polytetrafluoroethylene membranes: a light microscopical and histochemical time course study in the rabbit.
pubmed:affiliation
Dental School, University of Chieti, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't