Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-2-27
|
| pubmed:abstractText |
While PBSC collection has become a safe procedure for adults, only a few reports exist about its efficacy, safety and feasibility in paediatric patients, especially extremely low-weight infants. We describe successful PBSC collection in three infants of less than 10 kg body weight (BW; range: 6.92-9.4 kg) suffering from stage IV neuroblastoma. Harvest of PBSC started after mobilisation with high-dose chemotherapy and G-CSF, as soon as 1.0% CD34+ cells were detected. Collections were performed using a Baxter CS-3000 Plus separator primed with a mixture of irradiated, white cell-depleted and CMV-negative packed red cells resuspended in 5% human albumin and diluted with saline to match the patient's haematocrit. Performing a median of four, (4-7, median, range) procedures we collected at least 4 x 10(8)/kg BW nucleated cells (NC) from all three patients. The infants were not sedated and showed no serious side-effects. All three children were successfully transplanted with myeloid engraftment in 8 (7-9) days, independence from red cell support was achieved in 15 (10-20) days and from platelet transfusions in 25 (14-29) days after PBSC infusion. We conclude that PBSC harvesting using continuous flow cell separators is safe, even in low-weight infants of less than 7 kg BW.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
15-7
|
| pubmed:dateRevised |
2006-4-24
|
| pubmed:meshHeading |
pubmed-meshheading:8831990-Adrenal Gland Neoplasms,
pubmed-meshheading:8831990-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8831990-Body Weight,
pubmed-meshheading:8831990-Bone Marrow,
pubmed-meshheading:8831990-Cell Count,
pubmed-meshheading:8831990-Cyclophosphamide,
pubmed-meshheading:8831990-Doxorubicin,
pubmed-meshheading:8831990-Erythrocyte Transfusion,
pubmed-meshheading:8831990-Female,
pubmed-meshheading:8831990-Graft Survival,
pubmed-meshheading:8831990-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:8831990-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:8831990-Hematopoietic Stem Cells,
pubmed-meshheading:8831990-Humans,
pubmed-meshheading:8831990-Infant,
pubmed-meshheading:8831990-Leukapheresis,
pubmed-meshheading:8831990-Male,
pubmed-meshheading:8831990-Neuroblastoma,
pubmed-meshheading:8831990-Platelet Transfusion,
pubmed-meshheading:8831990-Vincristine
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Peripheral blood stem cell (PBSC) collection in extremely low-weight infants.
|
| pubmed:affiliation |
Department of Transfusion Medicine, University Hospital, Innsbruck, Austria.
|
| pubmed:publicationType |
Journal Article
|