Linked Life Data

8831799

Source:http://linkedlifedata.com/resource/pubmed/id/8831799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1996-10-31
pubmed:abstractText
The responses of two substrains of Balb/c mice (Epilepsy Prone and Epilepsy Resistant) to immunization with sheep red blood cells (SRBC) were examined to determine whether chronic neurochemical differences between the two strains could influence B cell function. Anti-SRBC IgG production in the Epilepsy Prone (EP) strain was reduced relative to the Epilepsy Resistant (ER) strain, while anti-SRBC IgM production was unaffected. No differences were found in in vitro antibody (Ab) production or T lymphocyte function between the EP and ER strains, suggesting that in vivo conditions rather than an intrinsic cellular defect are responsible for reduced IgG production by EP mice. Basal splenic norepinephrine (NE) levels were significantly higher in EP mice than those in ER mice, and remained significantly higher following immunization. ER mice treated with the beta 2 adrenergic agonist terbutaline on days 4, 5 and 6 after immunization produced significantly lower numbers of IgG PFC than did saline treated controls. Addition of NE during later stages of in vitro immunization suppressed both anti-SRBC IgM and IgG production by splenic lymphocytes from Balb/c mice, and NE was found to decrease IFN gamma production. These observations suggest that dysregulation of splenic NE can have an impact on the immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1121-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Role of norepinephrine in suppressed IgG production in epilepsy-prone mice.
pubmed:affiliation
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg. JGREEN-J@ACE.acadiau.ca
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't