Linked Life Data

8830935

Source:http://linkedlifedata.com/resource/pubmed/id/8830935

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-12-11
pubmed:abstractText
Because remnants of triglyceride-rich lipoproteins (TRLP) are potentially atherogenic, the postprandial lipoprotein metabolism was studied in 12 normocholesterolemic, normotriglyceridemic women, aged 60 +/- 2 years, with angiographically proven coronary artery disease (CAD+; cholesterol 5.7 +/- 0.1 (S.E.) mmol/l, triglyceride 1.35 +/- 0.10 mmol/l) and in 12 individually matched controls, aged 59 +/- 2 years, without angiographical abnormalities (CAD-; cholesterol 5.1 +/- 0.2 mmol/l and triglyceride 1.16 +/- 0.13 mmol/l). Following an oral retinyl palmitate-fat load, the CAD+ women showed a significantly higher triglyceride response in the chylomicron, or Sf > 1000, fraction (P < 0.05 vs. controls). Total plasma apolipoprotein (apo) B and retinyl palmitate concentrations were similar in both groups. Fasting apo B-48 levels in the d < 1.006 g/ml fraction were significantly higher in CAD+ cases (0.25 +/- 0.03 integrated optical density (iod) units) than CAD- controls (0.15 +/- 0.03; P < 0.05). Furthermore, after the fat load, a greater absolute and incremental apo B-48 response in the intermediate density lipoprotein (IDL) fraction (d = 1.006-1.019 g/ml) was observed in CAD+ cases (incremental area under the curve (Delta-AUC)8: 0.40 +/- 0.12 h.iod) than CAD- controls (0.01 +/- 0.06 h.iod; P = 0.01). Post-heparin hepatic lipase (HL) activities were higher in the CAD+ group: 422 +/- 22 mU/l vs 288 +/- 20 mU/ml in the CAD- group (P < 0.001) while lipoprotein lipase (LPL) activities were identical. The results provide evidence that the metabolism of intestinal TRLP is significantly different in normolipidemic women with angiographically proven CAD compared with individually matched controls without coronary disease. Fasting apo B-48 levels in d< 1.006 g/ml fractions represent a potentially useful marker in women at risk for CAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8830935-Analysis of Variance, pubmed-meshheading:8830935-Anticoagulants, pubmed-meshheading:8830935-Apolipoprotein B-48, pubmed-meshheading:8830935-Apolipoproteins B, pubmed-meshheading:8830935-Case-Control Studies, pubmed-meshheading:8830935-Cholesterol, pubmed-meshheading:8830935-Coronary Angiography, pubmed-meshheading:8830935-Coronary Disease, pubmed-meshheading:8830935-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:8830935-Female, pubmed-meshheading:8830935-Heparin, pubmed-meshheading:8830935-Humans, pubmed-meshheading:8830935-Lipoprotein Lipase, pubmed-meshheading:8830935-Lipoproteins, pubmed-meshheading:8830935-Lipoproteins, IDL, pubmed-meshheading:8830935-Liver, pubmed-meshheading:8830935-Middle Aged, pubmed-meshheading:8830935-Postprandial Period, pubmed-meshheading:8830935-Radioimmunoassay, pubmed-meshheading:8830935-Retrospective Studies, pubmed-meshheading:8830935-Risk Factors, pubmed-meshheading:8830935-Triglycerides, pubmed-meshheading:8830935-Ultracentrifugation, pubmed-meshheading:8830935-Vitamin A
pubmed:year
1996
pubmed:articleTitle
Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70% stenotic coronary artery disease: a case-control study.
pubmed:affiliation
Department of Internal Medicine and Endocrinology, Academic Hospital, Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't