Linked Life Data

8830274

Source:http://linkedlifedata.com/resource/pubmed/id/8830274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-10-17
pubmed:abstractText
Depletion of nutrients, including phosphate, is a stress often encountered by a bacterial cell, and results in slowed growth, marking the cessation of exponential growth. Genes that are transcriptionally activated during phosphate starvation have been used to examine the signal-transduction mechanisms governing the Pho regulon in Bacillus subtilis. Alkaline phosphatase, the traditional reporter protein for Pho regulation in prokaryotes, is encoded by a multigene family in B. subtilis. Characterization of the alkaline phosphatase family was a breakthrough in the study of regulation of the Pho regulon, especially the discovery of promoter elements exclusively responsive to phosphate-starvation regulation. Current data suggest that at least three two-component signal-transduction systems interact, forming a regulatory network that controls the phosphate-deficiency response in B. subtilis. The interconnected pathways involve the PhoP-PhoR system, whose primary role is to mediate the phosphate-deficiency response; the SpoO phosphorelay required for the initiation of sporulation; and a newly discovered signal-transduction system, ResD-ResE, which also has a role in respiratory regulation during late growth. Parallel pathways positively regulate the Pho response via PhoP-PhoR. One pathway includes the ResD-ResE system, while the other involves a transition-state regulator, AbrB. The SpoO system represses the Pho response by negatively regulating both pathways. This review will discuss how the characterization of the APase multigene family made possible studies which show that the Pho regulon in B. subtilis is regulated by the integrated action of the Res, Pho and Spo signal-transduction systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0950-382X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
933-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The signal-transduction network for Pho regulation in Bacillus subtilis.
pubmed:affiliation
University of Illinois at Chicago, Laboratory for Molecular Biology (M/C 567) 60607, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review