Linked Life Data

8829178

Source:http://linkedlifedata.com/resource/pubmed/id/8829178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-12-6
pubmed:abstractText
Light and confocal microscopy was used to study the anatomy and morphology of cat pancreatic ganglia. Intracellular microelectrodes were used to examine the electrophysiological properties of neurons in the head, body, and tail regions of the pancreas and to compare their responses to 5-hydroxytryptamine (5-HT). Pancreatic ganglia were oval shaped, joined by interconnecting nerves. Several head to tail gradients were found: (1) ganglion cell numbers decreased from head to tail; (2) the incidence of ongoing synaptic activity was higher for neurons located in the head region; (3) ganglion neurons in the head region received a greater number of converging synaptic inputs; (4) a greater percentage of neurons in the head region responded to 5-HT; (5) a greater percentage of neurons in the head region exhibited depolarizing responses mediated by 5-HT3 receptors; and (6) late slow-excitatory postsynaptic potentials recorded from neurons in the head region were more often antagonized by 5-HT1P receptor antagonists. It was concluded that cat pancreatic ganglia are sites of convergence and integration of synaptic inputs arriving from multiple sources. Serotonergic inputs from enteropancreatic nerves, if they exist in the cat pancreas, would be expected to have a significant influence on the excitability of neurons located in the head region compared to neurons located in the tail region of the pancreas.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0885-3177
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Cat pancreatic neurons: morphology, electrophysiological properties, and responses to 5-HT.
pubmed:affiliation
Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.