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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-11-5
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pubmed:abstractText |
Polymerase chain reaction (PCR) assays that detect fusion genes resulting from consistent chromosomal translocations have been used to detect minimal residual disease, primarily in hematologic malignancies. Molecular assays have been developed recently that detect the PAX3-FKHR or PAX7-FKHR fusion transcript resulting from the t(2; 13) or t(1; 13) translocation consistently observed in alveolar rhabdomyosarcoma. Because of the tumor's propensity to disseminate widely, our aim was to determine whether or not reverse transcriptase-PCR assays could detect submicroscopic disease in bone marrow or peripheral blood specimens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PAX3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PAX7 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/PAX7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Pax3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1320-7
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:8826957-Bone Marrow,
pubmed-meshheading:8826957-Bone Marrow Purging,
pubmed-meshheading:8826957-Bone Transplantation,
pubmed-meshheading:8826957-Chromosomes, Human, Pair 1,
pubmed-meshheading:8826957-Chromosomes, Human, Pair 13,
pubmed-meshheading:8826957-DNA-Binding Proteins,
pubmed-meshheading:8826957-Feasibility Studies,
pubmed-meshheading:8826957-Follow-Up Studies,
pubmed-meshheading:8826957-Forkhead Transcription Factors,
pubmed-meshheading:8826957-Homeodomain Proteins,
pubmed-meshheading:8826957-Humans,
pubmed-meshheading:8826957-Muscle Proteins,
pubmed-meshheading:8826957-Neoplasm Recurrence, Local,
pubmed-meshheading:8826957-Neoplasm Staging,
pubmed-meshheading:8826957-Nerve Tissue Proteins,
pubmed-meshheading:8826957-PAX7 Transcription Factor,
pubmed-meshheading:8826957-Paired Box Transcription Factors,
pubmed-meshheading:8826957-Polymerase Chain Reaction,
pubmed-meshheading:8826957-Prospective Studies,
pubmed-meshheading:8826957-RNA, Neoplasm,
pubmed-meshheading:8826957-Remission Induction,
pubmed-meshheading:8826957-Rhabdomyosarcoma, Alveolar,
pubmed-meshheading:8826957-Transcription, Genetic,
pubmed-meshheading:8826957-Transcription Factors,
pubmed-meshheading:8826957-Translocation, Genetic,
pubmed-meshheading:8826957-Treatment Outcome
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pubmed:year |
1996
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pubmed:articleTitle |
Minimal disease detection in patients with alveolar rhabdomyosarcoma using a reverse transcriptase-polymerase chain reaction method.
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pubmed:affiliation |
Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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