Linked Life Data

8825876

Source:http://linkedlifedata.com/resource/pubmed/id/8825876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-12-3
pubmed:abstractText
Oxygen plays an important role in cardiac function. Many methods have been applied to measure tissue oxygen tension (PO2). Electron paramagnetic resonance (EPR) oximetry appears to have some significant advantages for use in the beating heart. This study presents the serial measurement of myocardial PO2 by EPR oximetry in the isolated crystalloid perfused heart during changes of influent PO2, coronary flow rate, oxygen consumption and end-diastolic pressure. Baseline myocardial PO2 was 198 +/- 12 mmHg (mean +/- S.E.). Myocardial PO2 increased as expected with increased delivery (concentration or flow) or decreased consumption. With increasing flow rate, myocardial PO2 increased in a sigmoid fashion. A critical flow or pressure was reached when myocardial PO2 rapidly increased to a higher level. Increased left ventricular end-diastolic pressure caused local vascular compression and resulted in a decrease of myocardial PO2. Myocardial capillary density in the intact contracting heart was calculated to be 2300 +/- 110/mm2, using local myocardial PO2 and a cylindrical model for oxygen diffusion in tissue. Relative capillary density did not change with mild to moderate hypoxia, increased with increasing flow and increasing oxygen consumption and decreased with elevated diastolic pressure. We conclude that the application of EPR oximetry with LiPc to the isolated heart provides accurate and dynamic evaluation of local myocardial PO2 in the contracting heart. Using various models of oxygen delivery and diffusion in tissue, these data may also be used to serially follow capillary density.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2551-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Myocardial oxygen tension and relative capillary density in isolated perfused rat hearts.
pubmed:affiliation
Section of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't