Linked Life Data

8825304

Source:http://linkedlifedata.com/resource/pubmed/id/8825304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-12-5
pubmed:abstractText
Purified Coxiella burnetii (Nine Mile, phase I) ricketssiae were exposed to a synthetic peptide (CAP37(20-44)) based on the amino acid sequence of CAP37--a 37 K human neutrophil granule-associated cationic antimicrobial protein--and their capacity to infect L929 mouse fibroblast cells was assessed during a 10-day post-exposure period. Because the parasite thrives within the acidic phagolysosome we anticipated that CAP37(20-44) would have no adverse effect on the organism. This was borne out by the experiments; however, to our surprise, treated C. burnetii had a much greater capacity to infect L cells than the non-treated counterpart. We speculate that the peptide exhibits opsonin-like properties, enhancing attachment of the rickettsia to the host cell surface and subsequent entry.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-723X
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-226
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A cationic antimicrobial peptide enhances the infectivity of Coxiella burnetii.
pubmed:affiliation
Biology Department, University of New Mexico, Albuquerque 8713-1091, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't