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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-3-4
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pubmed:abstractText |
Genetic linkage analysis has previously mapped the locus for the autosomal dominant disorder branchio-oto-renal syndrome (BOR) to the pericentric region of chromosome 8q. A YAC contig spanning the putative BOR region, from D8S543 to D8S541, was constructed and confirmed by sequence-tagged site content mapping using microsatellite markers and by DNA hybridization analysis. YACs spanning the BOR interval were used as fluorescence in situ hybridization probes on a cell line from a patient with BO and tricho-rhino-phalangeal syndrome I that involves a chromosome 8q rearrangement. In addition to the cytogenetically defined direct insertion of material from 8q13.3-q21.13 into 8q24.11, a previously unidentified deletion of just under one megabase was found in 8q13.3. These data narrowed the most likely location of the BOR gene to a region corresponding to the proximal two-thirds of YAC 869E10 between D8S543 and D8S279.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0888-7543
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8824802-Abnormalities, Multiple,
pubmed-meshheading:8824802-Base Sequence,
pubmed-meshheading:8824802-Branchial Region,
pubmed-meshheading:8824802-Chromosome Mapping,
pubmed-meshheading:8824802-Chromosomes, Artificial, Yeast,
pubmed-meshheading:8824802-Cloning, Molecular,
pubmed-meshheading:8824802-DNA Primers,
pubmed-meshheading:8824802-Hearing Disorders,
pubmed-meshheading:8824802-Humans,
pubmed-meshheading:8824802-Kidney,
pubmed-meshheading:8824802-Langer-Giedion Syndrome,
pubmed-meshheading:8824802-Molecular Sequence Data,
pubmed-meshheading:8824802-Sequence Deletion
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pubmed:year |
1996
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pubmed:articleTitle |
Detection of a megabase deletion in a patient with branchio-oto-renal syndrome (BOR) and tricho-rhino-phalangeal syndrome (TRPS): implications for mapping and cloning the BOR gene.
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pubmed:affiliation |
Department of Biology and Institute for Molecular Biology, University of Houston, Texas 77204, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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