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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-12-4
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pubmed:abstractText |
Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by 51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
212
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-12
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8823750-Animals,
pubmed-meshheading:8823750-Antigens, CD,
pubmed-meshheading:8823750-Antigens, CD80,
pubmed-meshheading:8823750-Antigens, CD86,
pubmed-meshheading:8823750-Flow Cytometry,
pubmed-meshheading:8823750-Gene Expression,
pubmed-meshheading:8823750-Glioma,
pubmed-meshheading:8823750-Histocompatibility Antigens Class I,
pubmed-meshheading:8823750-Humans,
pubmed-meshheading:8823750-Insulin-Like Growth Factor I,
pubmed-meshheading:8823750-Insulin-Like Growth Factor II,
pubmed-meshheading:8823750-Membrane Glycoproteins,
pubmed-meshheading:8823750-Mice,
pubmed-meshheading:8823750-Neuroblastoma,
pubmed-meshheading:8823750-RNA, Antisense,
pubmed-meshheading:8823750-RNA, Messenger,
pubmed-meshheading:8823750-Rats,
pubmed-meshheading:8823750-Teratocarcinoma,
pubmed-meshheading:8823750-Transfection,
pubmed-meshheading:8823750-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA.
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pubmed:affiliation |
C.H.B. Hôpital Paul Brousse 12, Université Paris-Sud, Villejuif, France.
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pubmed:publicationType |
Journal Article
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