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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-10-30
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pubmed:abstractText |
The gene bcl-x, which is related to a bcl-2, regulates programmed cell death. bcl-x may function in the development of the nervous system. We raised a polyclonal antibody against human Bcl-x protein, and investigated its distribution in the developing human cerebellum. Western blotting revealed that Bcl-x expression in the cerebellum is higher in the fetal, than in the postnatal period. Immunohistochemical studies of fetal brains localized intense Bcl-x immunoreactivity in the granule cell processes at 13-22 gestational weeks and in the Purkinje cell bodies at 24-38 weeks. The immunoreactivity decreased after birth, but was retained in the Purkinje cells at a low level until adulthood. These results suggested that Bcl-x expression in the cerebellum is developmentally regulated and involved specifically in the development of neuronal subpopulations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0360-4012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8820965-Adult,
pubmed-meshheading:8820965-Amino Acid Sequence,
pubmed-meshheading:8820965-Antibodies, Monoclonal,
pubmed-meshheading:8820965-Apoptosis,
pubmed-meshheading:8820965-Blotting, Western,
pubmed-meshheading:8820965-Cerebellar Cortex,
pubmed-meshheading:8820965-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8820965-Female,
pubmed-meshheading:8820965-Humans,
pubmed-meshheading:8820965-Immunoenzyme Techniques,
pubmed-meshheading:8820965-Immunohistochemistry,
pubmed-meshheading:8820965-Infant,
pubmed-meshheading:8820965-Infant, Newborn,
pubmed-meshheading:8820965-Molecular Sequence Data,
pubmed-meshheading:8820965-Pregnancy,
pubmed-meshheading:8820965-Proto-Oncogene Proteins,
pubmed-meshheading:8820965-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8820965-Thymus Gland,
pubmed-meshheading:8820965-bcl-X Protein
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pubmed:year |
1996
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pubmed:articleTitle |
High expression of Bcl-x protein in the developing human cerebellar cortex.
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pubmed:affiliation |
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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