Linked Life Data

8820880

Source:http://linkedlifedata.com/resource/pubmed/id/8820880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-3-7
pubmed:abstractText
In the cochlea of the adult Bronx waltzer (bv/bv) mouse, the majority of inner hair cells are missing or deformed. As a result, Bronx waltzer mice are severely hearing impaired or deaf. Previous studies determined that most inner hair cells in these mice are missing by the time of birth, but no studies have resolved whether the missing inner hair cells ever exist in the mutant cochlea. The present study used light and electron microscopy to locate inner hair cells in the mutant mouse before birth. Most, and possibly all, inner hair cells exist in the embryonic day (E) 17 mouse. The shapes of the cells vary from normal and elongated in the youngest animals, to round and protruding through the reticular lamina a few days later. The density of sensory cells in the inner hair cell region (inner hair cells/millimeter) decreases in the basal turn between E17 and birth, and in the apical turn between birth and the third postnatal day. The initial presence of the full complement of inner hair cells, taken together with the temporospatial pattern of degeneration, suggests that the cause of inner hair cell death in the Bronx waltzer mouse is related to a differentiation event subsequent to cell birth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
364
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-522
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Cochlear inner hair cells exist transiently in the fetal Bronx Waltzer (bv/bv) mouse.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.