Linked Life Data

8819519

Source:http://linkedlifedata.com/resource/pubmed/id/8819519

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-11-5
pubmed:abstractText
Previous studies in this laboratory indicate in vivo administration of a single dose of ethanol (EtOH) can decrease basal and polyinosinic/polycytidilic acid-stimulated natural killer (NK) cell activity. In the present study, in vivo administration of EtOH also decreased interleukin-2-induced splenic NK cell activity measured 12 hr after administration of EtOH and interleukin-2. In vitro experiments were conducted in which the concentration and duration of exposure to interleukin-2, EtOH and the major metabolites of EtOH (acetaldehyde and acetate) were designed to match the conditions measured or expected in the in vivo experiments. EtOH and acetaldehyde decreased NK cell activity in a dose-dependent manner, but concentrations equivalent to those reported in blood caused relatively small decreases (< 20%) in NK cell activity. A combination of EtOH, acetaldehyde and acetate also suppressed NK cell activity, but suppression by concentrations comparable to those expected in vivo was less than 20%. By comparison, exposure to EtOH at similar concentrations and for similar times in vivo causes approximately 50% suppression of NK cell activity. Thus direct action of EtOH and its metabolites is not the primary mechanism by which NK cell activity is suppressed after administration of EtOH in vivo. This result suggests that other mechanisms, such as the induction of immunosuppressive neuroendocrine mediators, should be investigated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
278
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1325-30
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity.
pubmed:affiliation
Department of Biological Sciences, Mississippi State University, Mississippi State, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.