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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-5-2
|
| pubmed:abstractText |
Antagonism of saxitoxin-and tetrodotoxin-induced lethality by 4-aminopyridine was studied in urethane-anesthetized guinea pigs instrumented for the concurrent recordings of medullary respiratory-related unit activities (Bötzinger complex and Nu. para-Ambiguus), diaphragmatic electromyogram, electrocorticogram, Lead II electrocardiogram, blood pressure, end-tidal CO2 and arterial O2/CO2/pH. The toxin (either saxitoxin or tetrodotoxin) was infused at a dose rate of 0.3 microgram/kg/min (i.v.) to produce a state of progressive cardiorespiratory depression. The animals were artificially ventilated when the magnitude of integrated diaphragm activities was reduced to 50% of control. Immediately after the disappearance of the diaphragm electromyogram, the toxin infusion was terminated, and 4-aminopyridine (2 mg/kg, i.v.) was administered. The therapeutic effect of 4-aminopyridine was striking in that the toxin-induced blockade of diaphragmatic neurotransmission, vascular hypotension, myocardial anomalies, bradycardia and aberrant discharge patterns of medullary respiratory-related neurons could all be promptly restored to a level comparable to that of control condition. The animals were typically able to breathe spontaneously within minutes after 4-aminopyridine. At the dose level used to achieve the desired therapeutic responses, 4-aminopyridine produced no sign of seizure and convulsion. Although less serious side-effects such as cortical excitant/arousal and transient periods of fascicular twitch could be observed, these events were of minor concern, in our opinion, particularly in view of the remarkable therapeutic effects of 4-aminopyridine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0041-0101
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
671-90
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8817812-4-Aminopyridine,
pubmed-meshheading:8817812-Animals,
pubmed-meshheading:8817812-Blood Gas Analysis,
pubmed-meshheading:8817812-Blood Pressure,
pubmed-meshheading:8817812-Bradycardia,
pubmed-meshheading:8817812-Carbon Dioxide,
pubmed-meshheading:8817812-Diaphragm,
pubmed-meshheading:8817812-Electrocardiography,
pubmed-meshheading:8817812-Electromyography,
pubmed-meshheading:8817812-Electrophysiology,
pubmed-meshheading:8817812-Guinea Pigs,
pubmed-meshheading:8817812-Hydrogen-Ion Concentration,
pubmed-meshheading:8817812-Hypotension,
pubmed-meshheading:8817812-Infusions, Intravenous,
pubmed-meshheading:8817812-Male,
pubmed-meshheading:8817812-Neurons,
pubmed-meshheading:8817812-Oxygen Consumption,
pubmed-meshheading:8817812-Saxitoxin,
pubmed-meshheading:8817812-Synaptic Transmission,
pubmed-meshheading:8817812-Tetrodotoxin
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
4-Aminopyridine antagonizes saxitoxin-and tetrodotoxin-induced cardiorespiratory depression.
|
| pubmed:affiliation |
Neurotoxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425, USA.
|
| pubmed:publicationType |
Journal Article
|