Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-10-4
|
| pubmed:abstractText |
We studied the effects of high-dose methylprednisolone on the survival of intrastriatal neural xenografts and the host responses against them. Dissociated mesencephalic tissue from inbred mouse (CBA-strain) embryos was transplanted to the intact striatum of adult Sprague-Dawley rats. The rats received either daily injections of methylprednisolone (30 mg/kg), or cyclosporin A (10 mg/kg), or no immunosuppressive treatment. Two or six weeks after transplantation, there was good survival of xenografts in both the methylprednisolone- and cyclosporin A-treated rats. In contrast, the xenografts in untreated control rats were all rejected by six weeks. There was no marked difference in the degree of expression of MHC class I and II antigens and the accumulation of activated astrocytes and microglial cells/macrophages between the three groups. However, both methylprednisolone and cyclosporin A reduced infiltration of T lymphocytes to the transplantation sites. The expression of pro-inflammatory cytokines (interferon-gamma, tumour necrosis factor-alpha, interleukin-6) in and around the grafts was lower in the methylprednisolone- and cyclosporin A-treated groups than in untreated control rats. Although high-dose methylprednisolone caused significant body weight loss, we conclude that this treatment can prevent rejection of intrastriatal grafts of xenogeneic embryonic neural tissue in the adult.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Methylprednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
18
|
| pubmed:volume |
712
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
199-212
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8814894-Animals,
pubmed-meshheading:8814894-Brain Chemistry,
pubmed-meshheading:8814894-Brain Tissue Transplantation,
pubmed-meshheading:8814894-CD4-CD8 Ratio,
pubmed-meshheading:8814894-Cytokines,
pubmed-meshheading:8814894-Female,
pubmed-meshheading:8814894-Fetal Tissue Transplantation,
pubmed-meshheading:8814894-Glial Fibrillary Acidic Protein,
pubmed-meshheading:8814894-Graft Rejection,
pubmed-meshheading:8814894-Graft Survival,
pubmed-meshheading:8814894-Immunohistochemistry,
pubmed-meshheading:8814894-Immunosuppressive Agents,
pubmed-meshheading:8814894-Major Histocompatibility Complex,
pubmed-meshheading:8814894-Methylprednisolone,
pubmed-meshheading:8814894-Mice,
pubmed-meshheading:8814894-Neostriatum,
pubmed-meshheading:8814894-Pregnancy,
pubmed-meshheading:8814894-Rats,
pubmed-meshheading:8814894-Rats, Sprague-Dawley,
pubmed-meshheading:8814894-Receptors, Complement,
pubmed-meshheading:8814894-Transplantation, Heterologous,
pubmed-meshheading:8814894-Tyrosine 3-Monooxygenase
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Methylprednisolone prevents rejection of intrastriatal grafts of xenogeneic embryonic neural tissue in adult rats.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|