Linked Life Data

8813145

Source:http://linkedlifedata.com/resource/pubmed/id/8813145

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1996-11-21
pubmed:abstractText
Considerable molecular genetic and cytogenetic evidence indicates that chromosome 11 is a target for chromosome breakage, rearrangement, and loss during the development of human malignant melanomas. Abnormalities of the long arm of chromosome 11 are also evident in a wide variety of other human solid tumors, including carcinomas of the breast, ovary, cervix, and lung. In melanomas, these abnormalities tend to cluster in the lower half of the long arm of chromosome 11, indicating the possible presence of a melanoma tumor suppressor gene in this region. We tested this possibility by using microcell-mediated chromosome transfer to introduce normal copies of human chromosome 11 into two human malignant melanoma cell lines. In one cell line, MelJuSo, the presence of an additional copy of chromosome 11 severely reduced the ability of the cells to grow in culture. In a second cell line, UACC 903, there was a moderate reduction in cell growth in vitro, and the ability of the hybrid cells to form tumors in animals was suppressed. Suppression of tumorigenicity was even more strongly pronounced in a microcell hybrid that received an isochromosome 11q derived from the donor copy of chromosome 11. The formation of tumors was accompanied by a reduction in the copy number of chromosome 11. This provides functional evidence that a melanoma tumor suppressor resides on the long arm of chromosome 11. Thus, a third distinct locus, in addition to those previously defined on chromosomes 6 and 9, appears to play a role in the development of human malignant melanoma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4487-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
A malignant melanoma tumor suppressor on human chromosome 11.
pubmed:affiliation
Division of Biomedical Sciences, University of California, Riverside 92521, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't