Linked Life Data

881289

Source:http://linkedlifedata.com/resource/pubmed/id/881289

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-9-17
pubmed:abstractText
An examination of the properties and reactivity of S-carboxymethylcysteine sulfone indicated that, unlike S-carboxymethylcysteine, the sulfone is not stable under acid hydrolysis conditions and decomposes to yield alanine. Unlike S-carboxymethylcysteine, the sulfone is resistant to N-derivatization by the dansyl reagent or by phenylisothiocyanate. Efforts were made to determine if spontaneous cyclization of the sulfone to the corresponding thiazane (lactam) accounts for lack of reactivity. These included i.r. spectroscopy, natural abundance 13C-n.m.r. spectroscopy and differential scanning calorimetry, but yielded equivocal results concerning the existence of the cyclic form in solution. Solubility behavior of the sulfone after lyophilization from strongly acid solutions was consistent with conversion of the open chain form to the cyclic form on addition of water.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0367-8377
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
S-carboxymethylcysteine sulfone: instability to acid hydrolysis and unreactivity with N-terminal reagents.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.