Linked Life Data

8812066

Source:http://linkedlifedata.com/resource/pubmed/id/8812066

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-12-6
pubmed:abstractText
To better understand the regulatory processes underlying axonal pathfinding we analyzed the embryonic expression of seven murine semaphorin genes by in situ hybridization In the spinal cord, transcripts of all seven semaphorin genes were detected from Embryonic Day 11.5 (E11.5) onward and restricted to distinct regions at E15.5. Interestingly, semE, F, and G mRNAs were in addition differentially expressed in the ventricular zone of the telencephalon. In order to correlate these expression patterns to the behavior of different types of sensory afferents, we tested their response to recombinant semaphorin proteins. Specific subpopulations of dorsal root ganglion sensory neurons displayed a developmentally regulated differential response to Sem D. Whereas extension of both NGF- and NT-3-dependent neurites was inhibited by Sem D at E12.5, only neurites formed in the presence of NGF responded at E14.5. This suggests that Sem D may be involved in preventing an early penetration of the spinal cord by sensory afferents and subsequently shaping their lamina-specific termination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1044-7431
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins.
pubmed:affiliation
Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt/Main, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't