| pubmed-article:8809678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0229535 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0032016 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0037668 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C2751021 | lld:lifeskim |
| pubmed-article:8809678 | lifeskim:mentions | umls-concept:C0815016 | lld:lifeskim |
| pubmed-article:8809678 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8809678 | pubmed:dateCreated | 1996-11-21 | lld:pubmed |
| pubmed-article:8809678 | pubmed:abstractText | To examine the effects of glucocorticoid (GC) on growth hormone (GH)-releasing hormone (GRH) receptor gene expression, a highly-sensitive and quantitative reverse-transcribed polymerase chain reaction (RT-PCR) method was used in this study. Rat anterior pituitary cells were isolated and cultured for 4 days. The cultured cells were treated with dexamethasone for 2, 6, and 24 h. GRH receptor mRNA levels were determined by competitive RT-PCR using a recombinant RNA as the competitor. Dexamethasone significantly increased GRH receptor mRNA levels at 5 nM after 6- and 24 h-incubations, and the maximal effect was found at 25 nM. The GC receptor-specific antagonist, RU 38486 completely eliminated the dexamethasone-induced enhancement of GRH receptor mRNA levels. Dexamethasone did not alter the mRNA levels of beta-actin and prolactin at 5 nM for 24 h, whereas GH mRNA levels were significantly increased by the same treatment. The GH response to GRH was significantly enhanced by the 24-h incubation with 5 nM dexamethasone. These findings suggest that GC stimulates GRH receptor gene expression through the ligand-activated GC receptors in the rat somatotrophs. The direct effects of GC on the GRH receptor gene could explain the enhancement of GRH-induced GH secretion. | lld:pubmed |
| pubmed-article:8809678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8809678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8809678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8809678 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8809678 | pubmed:issn | 0953-8194 | lld:pubmed |
| pubmed-article:8809678 | pubmed:author | pubmed-author:MatsubaraSS | lld:pubmed |
| pubmed-article:8809678 | pubmed:author | pubmed-author:TakaharaJJ | lld:pubmed |
| pubmed-article:8809678 | pubmed:author | pubmed-author:WadaYY | lld:pubmed |
| pubmed-article:8809678 | pubmed:author | pubmed-author:SatoMM | lld:pubmed |
| pubmed-article:8809678 | pubmed:author | pubmed-author:TamakiMM | lld:pubmed |
| pubmed-article:8809678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8809678 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:8809678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8809678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8809678 | pubmed:pagination | 475-80 | lld:pubmed |
| pubmed-article:8809678 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8809678 | pubmed:meshHeading | pubmed-meshheading:8809678-... | lld:pubmed |
| pubmed-article:8809678 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8809678 | pubmed:articleTitle | Dexamethasone increases growth hormone (GH)-releasing hormone (GRH) receptor mRNA levels in cultured rat anterior pituitary cells. | lld:pubmed |
| pubmed-article:8809678 | pubmed:affiliation | First Department of Internal Medicine, Kagawa Medical School, Japan. | lld:pubmed |
| pubmed-article:8809678 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8809678 | lld:pubmed |
