Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-10-25
|
| pubmed:abstractText |
The relative importance of reduced plasma high density lipoprotein-cholesterol (HDL-C) levels and elevated plasma triglyceride (TG) concentrations as risk factors for ischemic heart disease (IHD) was examined in a sample of 2177 men from the Québec City suburbs. The sample included 202 men with known IHD. The relationship between HDL-C and TG levels, although significant (r = -0.49, P < 0.0001), was not linear, as most of the variation in HDL-C levels was observed within TG levels below 2.5 mmol/l. Reduced HDL-C (< 0.9 mmol/l) was a prevalent condition in men with IHD (50%) compared to those without IHD (30%). On the other hand 26% and 20% of men with and without IHD, respectively, had elevated TG levels (TG > 2.3 mmol/l). A 2-fold increase in prevalence odds ratio (OR) was observed in men with TG levels > 2.3 mmol/l (95% confidence intervals (CI) [1.2;3.3]). No residual association between elevated TG levels and IHD was found, however, after adjustment for HDL-C concentrations (OR 1.2, 95% CI 0.7;2.1). On the other hand, HDL-C remained a significant predictor of IHD after adjustment for other risk factors (OR 0.3, 95%, CI 0.2;0.6). Men with reduced HDL-C levels were also characterized by a cluster of risk factors such as obesity, diabetes mellitus and hypertension, which may contribute to increase the risk of IHD. Finally, the independent interpretation of cholesterol, TG or LDL-C levels may lead to an inadequate prediction of risk, as a large number of IHD patients showed a cluster of risk factors which included low HDL-C concentrations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0021-9150
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
235-45
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8808500-Adult,
pubmed-meshheading:8808500-Alcohol Drinking,
pubmed-meshheading:8808500-Cholesterol, HDL,
pubmed-meshheading:8808500-Cohort Studies,
pubmed-meshheading:8808500-Comorbidity,
pubmed-meshheading:8808500-Disease Susceptibility,
pubmed-meshheading:8808500-Electrocardiography,
pubmed-meshheading:8808500-Humans,
pubmed-meshheading:8808500-Hypertriglyceridemia,
pubmed-meshheading:8808500-Infant,
pubmed-meshheading:8808500-Lipids,
pubmed-meshheading:8808500-Male,
pubmed-meshheading:8808500-Mass Screening,
pubmed-meshheading:8808500-Middle Aged,
pubmed-meshheading:8808500-Myocardial Ischemia,
pubmed-meshheading:8808500-Obesity,
pubmed-meshheading:8808500-Phenotype,
pubmed-meshheading:8808500-Prevalence,
pubmed-meshheading:8808500-Quebec,
pubmed-meshheading:8808500-Risk Factors,
pubmed-meshheading:8808500-Triglycerides
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Triglycerides and HDL-cholesterol as risk factors for ischemic heart disease. Results from the Québec cardiovascular study.
|
| pubmed:affiliation |
Lipid Research Center, CHUL Research Center, Montréal, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|