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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-2-4
|
| pubmed:abstractText |
Human immunodeficiency virus (HIV) replication depends on the interaction of an HIV regulatory protein, Rev, with a viral RNA element (the Rev-responsive element, RRE). The high affinity RRE core region contains a non-canonical base pair (G48:G71) that is important for Rev recognition. Aminoglycoside antibiotics, specifically neomycin B, bind to the RRE and selectively block Rev-RRE interactions in vivo and in vitro. We attempted to generate an in vitro model for the establishment of HIV-1 resistance to neomycin B.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1074-5521
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
129-37
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8807838-Base Composition,
pubmed-meshheading:8807838-Base Sequence,
pubmed-meshheading:8807838-DNA, Viral,
pubmed-meshheading:8807838-Drug Resistance, Microbial,
pubmed-meshheading:8807838-Framycetin,
pubmed-meshheading:8807838-Gene Products, rev,
pubmed-meshheading:8807838-HIV,
pubmed-meshheading:8807838-Molecular Sequence Data,
pubmed-meshheading:8807838-Point Mutation,
pubmed-meshheading:8807838-Protein Binding,
pubmed-meshheading:8807838-rev Gene Products, Human Immunodeficiency Virus
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
A non-canonical base pair within the human immunodeficiency virus rev-responsive element is involved in both rev and small molecule recognition.
|
| pubmed:affiliation |
Program in Molecular Medicine, Howard Hughes Medical Institute, UMASS Medical Center, Worcester, MA, 01605, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|