Linked Life Data

880770

Source:http://linkedlifedata.com/resource/pubmed/id/880770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
125
pubmed:dateCreated
1977-9-17
pubmed:abstractText
The Hall model of experimental arthritis of the knee (excision of the lateral femoral condyle) offers a unique way of investigating the earliest changes of degenerative arthritis. Predictable degeneration of the lateral tibial plateau occurs when there is lack of contact with an opposing surface. Previous work by Hall and Thompson has not concentrated upon the early changes in proven mature animals of optimum age for a study of simulated osteoarthritis. In this work using mature rabbits, two important findings are documented. The earliest observed change in the joint, beginning at 7 days is loss of matrix protein-polysaccharides from the lateral plateau, with no evidence of change in the subchondral bone until much later; in this respect mature differ from immature animals. Furthermore, there is strong evidence for late (three to 6 months) protein-polysaccharide synthesis in the previously degeneraing articular cartilage in which the residual cells reconstitute an effective matrix.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-6
pubmed:dateRevised
2005-3-3
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Experimental arthritis in rabbit knees: a study of relief of pressure on one tibial plateau in immature and mature rabbits.
pubmed:publicationType
Journal Article