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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-11-5
|
| pubmed:abstractText |
We compared the tumorigenic effects of the N-ras oncogene and the N-ras proto-oncogene in lymphoid and mammary tissues in an in vivo model. For this purpose, we generated transgenic mice with high levels of N-ras oncogene or N-ras proto-oncogene expression, driven by the complete mouse mammary tumor virus LTR (MMTV-LTR) (MMTV/N-rasT and MMTV/N-rasN constructs) and transgenic mice with low levels of N-ras oncogene or N-ras proto-oncogene expression, driven by a truncated MMTV-LTR (TMTV/N-rasT and TMTV/N-rasN constructs). We show that both, the N-ras proto-oncogene and the N-ras oncogene with a C:G-->A:T mutation at codon 61, lead to identical tumor types: lymphoblastic T-cell lymphomas, cleaved B-cell lymphomas and poorly differentiated mammary carcinomas. Nevertheless, there were quantitative differences in tumor incidence and latency and in transgene expression among N-ras oncogene and N-ras proto-oncogene transgenics. Despite these differences in tumor kinetics, the predisposition to identical tumor types is in agreement with the idea that the N-ras oncogene and the N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis in B-cells, T-cells or mammary epithelial cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1053-63
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8806695-Animals,
pubmed-meshheading:8806695-Breast,
pubmed-meshheading:8806695-Carcinoma,
pubmed-meshheading:8806695-Flow Cytometry,
pubmed-meshheading:8806695-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8806695-Genes, ras,
pubmed-meshheading:8806695-Incidence,
pubmed-meshheading:8806695-Lymphoma, B-Cell,
pubmed-meshheading:8806695-Lymphoma, T-Cell,
pubmed-meshheading:8806695-Mammary Neoplasms, Experimental,
pubmed-meshheading:8806695-Mammary Tumor Virus, Mouse,
pubmed-meshheading:8806695-Mice,
pubmed-meshheading:8806695-Mice, Transgenic,
pubmed-meshheading:8806695-Mutation,
pubmed-meshheading:8806695-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8806695-Signal Transduction,
pubmed-meshheading:8806695-Spleen,
pubmed-meshheading:8806695-Transcription, Genetic,
pubmed-meshheading:8806695-ras Proteins
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis.
|
| pubmed:affiliation |
Department of Pathology, New York University Medical Center, NY 10016, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|