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| pubmed-article:8806494 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8806494 | pubmed:dateCreated | 1996-10-31 | lld:pubmed |
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| pubmed-article:8806494 | pubmed:abstractText | Rous sarcoma virus (RSV) mainly replicates in avian fibroblasts, and the U3 enhancer region of the long terminal repeats of RSV contains the determinants for its tissue-tropic expression. We describe the cloning and characterization of an avian gene that encodes a protein capable of binding to the enhancer region of Rous sarcoma virus. A PCR-derived probe corresponding to the U3 region of RSV was used to isolate a cDNA clone by screening a chicken cDNA expression library. The cDNA is predicted to encode a polypeptide of 298 amino acids that is homologous to the Y-box (inverted CCAAT) family of DNA-binding transcription factors. This factor, which we refer to as Rous sarcoma virus enhancer factor-II (RSV-EF-II), shows 99% aa identity over a 105-amino-acid stretch that is highly conserved in all Y-box proteins, and is commonly referred to as the cold shock domain. RSV-EF-II selectively binds to single-stranded DNA, and the binding site, as determined by electrophoretic mobility shift assays, consists of the sequence 5' GTACCACC 3' located between nucleotides -112 to -119 in the noncoding strand of the RSV enhancer. Although RSV-EF-II shares considerable homology with the Y-box family of proteins, it does not bind to the inverted CCAAT boxes at positions -65 to -69 and -129 to -133 in the RSV LTR. Northern analysis indicates that RSV-EF-II-specific transcripts are expressed predominantly in avian fibroblasts and muscle tissue. The results of these binding and mRNA expression expriments suggest that RSV-EF-II may play an important role in tissue- and host-specific expression of RSV LTR-driven gene expression. Further, we show that RSV-EF-II acts as a repressor of transcription. | lld:pubmed |
| pubmed-article:8806494 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8806494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8806494 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8806494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8806494 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8806494 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:GuntakaR VRV | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:NambiarAA | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:KandalaJ CJC | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:CleavingerP... | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:ShinB ABA | lld:pubmed |
| pubmed-article:8806494 | pubmed:author | pubmed-author:SwamynathanS... | lld:pubmed |
| pubmed-article:8806494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8806494 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8806494 | pubmed:volume | 222 | lld:pubmed |
| pubmed-article:8806494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8806494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8806494 | pubmed:pagination | 133-43 | lld:pubmed |
| pubmed-article:8806494 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8806494 | pubmed:meshHeading | pubmed-meshheading:8806494-... | lld:pubmed |
| pubmed-article:8806494 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8806494 | pubmed:articleTitle | Cloning of Rous sarcoma virus enhancer factor genes. II. RSV-EF-II, abundantly expressed in fibroblasts and muscle tissue, binds to an octamer sequence, 5'-GTACCACC-3', in the noncoding strand of RSV enhancer. | lld:pubmed |
| pubmed-article:8806494 | pubmed:affiliation | Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia 65212, USA. | lld:pubmed |
| pubmed-article:8806494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8806494 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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