Linked Life Data

8806237

Source:http://linkedlifedata.com/resource/pubmed/id/8806237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-11-12
pubmed:abstractText
Apoptotic DNA fragmentation was observed 60 min after photodynamic therapy of murine leukemia cells in culture, using either of two photosensitizers with predominantly lysosomal targets. When the radical scavengers trolox or alpha-tocopherol succinate were present during irradiation, the subsequent appearance of apoptotic cells was prevented, as was phototoxicity. Addition of either scavenger during the 60 min after irradiation provided only partial protection from apoptosis and phototoxicity; this protection was abolished if the addition was delayed for 10 min. These results are consistent with a model whereby long-persisting photoproducts continue the initiation of apoptosis for approximately 10 min after irradiation has ceased.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-8655
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Delayed oxidative photodamage induced by photodynamic therapy.
pubmed:affiliation
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA. DHKESSEL@med.wayne.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.