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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-4-30
|
| pubmed:databankReference | |
| pubmed:abstractText |
HIV-1 reverse transcriptase (RT) is a major target for anti-HIV drugs. A considerable amount of information about the structure of RT is available, both unliganded and in complex with template-primer or non-nucleoside RT inhibitors (NNRTIs). But significant conformational differences in the p66 polymerase domain among the unliganded structures have complicated the interpretation of these data, leading to different proposals for the mechanisms of polymerization and inhibition.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0969-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
853-60
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8805568-Anti-HIV Agents,
pubmed-meshheading:8805568-Binding Sites,
pubmed-meshheading:8805568-Biopolymers,
pubmed-meshheading:8805568-HIV Reverse Transcriptase,
pubmed-meshheading:8805568-HIV-1,
pubmed-meshheading:8805568-Molecular Sequence Data,
pubmed-meshheading:8805568-Protein Conformation,
pubmed-meshheading:8805568-Reverse Transcriptase Inhibitors,
pubmed-meshheading:8805568-X-Ray Diffraction
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.
|
| pubmed:affiliation |
Center for Advanced Biotechnology and Medicine (CABM), Piscataway, NJ, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|