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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1996-11-7
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pubmed:abstractText |
Expression of the homeobox-containing gene Engrailed (En) in an increasing rostral-to-caudal gradient in the dorsal mesencephalon is the earliest known marker for polarity of the chick optic tectum. In heterotopic transplantation experiments, En protein expression correlates well with the subsequent gradient of cytoarchitecture as well as the pattern of retinotectal projections. The En gradient also correlates with the expression of two putative retinal axon-guidance molecules, RAGS and ELF-1, which are Eph-like receptor tyrosine kinase ligands that may function in the establishment of retinotopic projections by excluding temporal axons from the caudal tectum.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0960-9822
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
|
pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1006-14
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:8805331-Animals,
pubmed-meshheading:8805331-Axons,
pubmed-meshheading:8805331-Chick Embryo,
pubmed-meshheading:8805331-Embryonic and Fetal Development,
pubmed-meshheading:8805331-Gene Expression Regulation, Developmental,
pubmed-meshheading:8805331-Genes, Homeobox,
pubmed-meshheading:8805331-Genetic Vectors,
pubmed-meshheading:8805331-Homeodomain Proteins,
pubmed-meshheading:8805331-Mice,
pubmed-meshheading:8805331-Retroviridae,
pubmed-meshheading:8805331-Superior Colliculi,
pubmed-meshheading:8805331-Transfection
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pubmed:year |
1996
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pubmed:articleTitle |
Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression.
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pubmed:affiliation |
Department of Developmental Neurobiology, UMDS, Guy's Hospital, London SE1 9RT, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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