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pubmed:abstractText |
Genetic abnormalities in the Fas receptor or its trimeric ligand, FasL, result in massive T-cell proliferation and a lupus-like autoimmune syndrome, which was initially attributed to excessive lymphoproliferation but is now ascribed to the absence of Fas-mediated cell death. Although Fas is normally expressed on most thymocytes, negative selection seems to be unperturbed in Fas-deficient (lpr) mice. This suggests that Fas has an important function in peripheral, but not thymic, T cells.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, California 94305, USA. dspencer@bcm.tmc.edu
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