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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-12-3
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pubmed:abstractText |
Many birth defects are believed to involve gene-environment interactions, although the mechanisms involved are poorly understood. Apoptosis is a common effect of many kinds of environmental stresses on the developing embryo; therefore, mechanisms of teratogenesis may be approached within the context of the cell death program. The p53 tumor suppressor gene encodes a transcription factor which functions as a critical regulator of apoptosis in response to environmental stress.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8805222-Abnormalities, Drug-Induced,
pubmed-meshheading:8805222-Animals,
pubmed-meshheading:8805222-Apoptosis,
pubmed-meshheading:8805222-Base Sequence,
pubmed-meshheading:8805222-Cladribine,
pubmed-meshheading:8805222-DNA Primers,
pubmed-meshheading:8805222-Deoxyadenine Nucleotides,
pubmed-meshheading:8805222-Eye Abnormalities,
pubmed-meshheading:8805222-Female,
pubmed-meshheading:8805222-Gene Expression,
pubmed-meshheading:8805222-Male,
pubmed-meshheading:8805222-Mice,
pubmed-meshheading:8805222-Mice, Inbred C57BL,
pubmed-meshheading:8805222-Molecular Sequence Data,
pubmed-meshheading:8805222-Teratogens,
pubmed-meshheading:8805222-Tumor Suppressor Protein p53
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pubmed:year |
1996
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pubmed:articleTitle |
Teratogen-induced eye defects mediated by p53-dependent apoptosis.
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pubmed:affiliation |
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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