Linked Life Data

8803932

Source:http://linkedlifedata.com/resource/pubmed/id/8803932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-11-22
pubmed:abstractText
The renin-angiotensin system has been considered to be a circulating system that controls blood pressure and electrolyte homeostasis. It is now clear, however, that the renin-angiotensin system must also be regarded as a local tissue system within many organs. Renin-angiotensin system peptides are capable of producing the hyperplasia and growth of cells. The haematopoietic bone-marrow system is characterized by turnover, proliferation and differentiation of cells. We propose that there exists a locally active renin-angiotensin system that is intrinsic to bone marrow and that might affect the growth of haematopoietic colonies, and the production, proliferation and differentiation of cells. The local synthesis of a particular protein can be deduced from the presence of the corresponding messenger ribonucleic acid. To prove our hypothesis, we propose that attempts be made to quantitatively analyse messenger ribonucleic acids for components of the renin-angiotensin system in tissues from bone marrow biopsies. Demonstration of an endogenous renin-angiotension system in bone marrow might lead us to a better understanding of the production of haematopoietic cells and of the excessive cell-growth associated with neoplastic diseases of the blood.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-10
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
A local renin-angiotensin system in the bone marrow.
pubmed:affiliation
Department of Haematology, Hacettepe University Medical School, Ankara, Turkey.
pubmed:publicationType
Journal Article