Linked Life Data

8801598

Source:http://linkedlifedata.com/resource/pubmed/id/8801598

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-9-30
pubmed:abstractText
The purpose of the present experiment was to replicate previously reported observations of a relationship between saccharin consumption and oral ethanol self-administration in rats using operant measures (2,8) and to determine whether saccharin intake was related to the rate of acquisition of IV cocaine self-administration. Groups of Wistar rats selected for high and low saccharin (0.1% wt/vol) intake were tested for rate of acquisition of IV cocaine (0.2 mg/kg/infusion) self-administration using an autoshaping procedure. They were subsequently tested for self-administration of oral ethanol (8% wt/vol) under ascending fixed-ratio (FR) schedules (FR 1, 2, 4, and 8). Finally, ethanol deliveries were compared under food-deprivation and food-satiation conditions under an FR 8 schedule. Saccharin intake was redetermined after each phase of the experiment. No significant differences between high and low saccharin groups were found in rate of acquisition of IV cocaine self-administration, and there was not a significant correlation between saccharin and cocaine consumption. However, the high saccharin group drank significantly more ethanol than the low saccharin group during the FR 8 food satiation component. A significant correlation between saccharin and ethanol consumption was also found. For high and low saccharin groups, responding for ethanol increased proportionally with increases in FR such that consumption of ethanol remained relatively constant as FR increased. Ethanol consumption was significantly increased under food deprivation relative to food satiation conditions for both saccharin groups. A significant correlation between ethanol consumption and cocaine consumption was also found. Significant increases in saccharin consumption across successive saccharin consumption tests were found for both groups, although relative intake for the high and low saccharin groups remained stable throughout the experiment. These results indicate that higher ethanol intake is predicted by higher saccharin intake, but saccharin intake did not predict the rate of acquisition of IV cocaine self-administration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
919-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The relationships among saccharin consumption, oral ethanol, and i.v. cocaine self-administration.
pubmed:affiliation
Department of Psychiatry, University of Minnesota, School of Medicine, Minneapolis 55455, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.