Linked Life Data

8801571

Source:http://linkedlifedata.com/resource/pubmed/id/8801571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-9-30
pubmed:abstractText
The effects of acutely administered diazepam and the beta-carboline abecarnil were examined in two animal models of anxiety in rats, and for their effects on food intake and locomotor activity. In the elevated x-maze diazepam (0.6-2.5 mg/kg) and abecarnil (0.03-0.3 mg/kg) induced anxiolytic-like effects. The second paradigm is based upon the suppression of feeding by exposure to a novel environment, adapted from Bodnoff et al. (1989). Food-deprived rats were placed in a corner of the open field containing food in the centre. The number of rats beginning to eat in the first 5 min was recorded. Diazepam (2.5-5.0 mg/kg) and abecarnil (0.01-0.3 mg/kg) increased the number of rats eating. Flumazenil, the benzodiazepine antagonist, was without effect, but antagonised the effects of diazepam and abecarnil. In a seperate series of experiments the effects of diazepam and abecarnil on feeding and locomotor activity were excluded as having influenced the the anxiolytic effects of these compounds in the animal models of anxiety.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1005-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
"Anxiolytic" action of diazepam and abecarnil in a modified open field test.
pubmed:affiliation
Institute of Pharmacology and Toxicology, Humboldt-University, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't