Linked Life Data

8801272

Source:http://linkedlifedata.com/resource/pubmed/id/8801272

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-10-2
pubmed:abstractText
Anatomical, physiological and pharmacological evidence suggests that vasoactive intestinal polypeptide neurons are important mediators of the descending inhibitory component of intestinal peristalsis. Pharmacological data also indicate that glutamate may modulate intestinal motility. Recently, we demonstrated that mRNA coding for the glutamate N-methyl-D-aspartate (NMDA) receptor is expressed by rat enteric neurons. In order to ascertain whether NMDA receptor message is expressed by vasoactive intestinal polypeptide (VIP) neurons, we employed a double in situ hybridization technique. We hybridized tissue sections from the stomach, ileum and descending colon of adult rats with an NMDAR1 oligoprobe and a VIP oligonucleotide. Enteric neurons expressing mRNA for both NMDA and VIP were found in the myenteric and submucosal ganglia at all of the sampling sites. These data suggest that the mechanism for glutamatergic excitation is present in VIP-containing enteric neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-1838
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Expression of mRNA for the N-methyl-D-aspartate (NMDAR1) receptor and vasoactive intestinal polypeptide (VIP) co-exist in enteric neurons of the rat.
pubmed:affiliation
Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
pubmed:publicationType
Journal Article