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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021853,
umls-concept:C0034790,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205147,
umls-concept:C0205419,
umls-concept:C0242568,
umls-concept:C0330390,
umls-concept:C0443281,
umls-concept:C0457083,
umls-concept:C0521457,
umls-concept:C0699819,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
1996-10-1
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pubmed:abstractText |
A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominance. V beta dominance was also shown in the T cells of the colonic lamina propria. Analysis of two separate regions of intestine from the same patient (5-100 cm apart) showed that T cells expressing a dominant V beta region were often present at both sites. In most patients, however, major biases in T cell V beta usage (two to 12-fold variation) were also apparent between the two sites. Analysis of V beta expression in human fetal intestine also showed considerable skewing, although the most common dominant V beta in postnatal intestine (V beta 22) was never predominant in fetal intestine. Patchy local variation in the expression of individual V beta s therefore occurs against a background of V beta dominance over large regions of the human gut. Furthermore the results from fetal gut show that factors other than luminal antigen control V beta expression in the gut.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-1371494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-1730926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-1829988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-1833201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-1836473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-2423435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-2577122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-2960770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-3456338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-3492290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-3536221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-6345034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-6577996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-6795109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-6997989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-768378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-7688787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-7931067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8801195-7931068
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8801195-Adolescent,
pubmed-meshheading:8801195-Adult,
pubmed-meshheading:8801195-Case-Control Studies,
pubmed-meshheading:8801195-Cells, Cultured,
pubmed-meshheading:8801195-Female,
pubmed-meshheading:8801195-Gene Expression,
pubmed-meshheading:8801195-Humans,
pubmed-meshheading:8801195-Intestinal Mucosa,
pubmed-meshheading:8801195-Male,
pubmed-meshheading:8801195-Middle Aged,
pubmed-meshheading:8801195-Receptors, Antigen, T-Cell
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pubmed:year |
1996
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pubmed:articleTitle |
T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.
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pubmed:affiliation |
Department of Paediatric Gastroenterology, Medical College of St Bartholomew's Hospital, London.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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