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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-10-2
|
| pubmed:abstractText |
Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia characterized by the morphology of the blast cells, a specific t(15;17) translocation, and risks of definite coagulopathy. Recently this leukemia was further characterized by an exquisite sensitivity to all-trans retinoic acid's differentiation effect and the production of a fusion gene altering the gene of RARalpha and a novel gene PML. In vivo differentiation therapy with retinoids in APL patients follows strict guidelines related both to the APL cell and the biodisposal of all-trans retinoic acid.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0892-6638
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1025-30
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:8801163-Antineoplastic Agents,
pubmed-meshheading:8801163-Cell Differentiation,
pubmed-meshheading:8801163-Drug Resistance,
pubmed-meshheading:8801163-Humans,
pubmed-meshheading:8801163-Isomerism,
pubmed-meshheading:8801163-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:8801163-Neutrophils,
pubmed-meshheading:8801163-Receptors, Retinoic Acid,
pubmed-meshheading:8801163-Recurrence,
pubmed-meshheading:8801163-Tretinoin
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Retinoid differentiation therapy in promyelocytic leukemia.
|
| pubmed:affiliation |
Hopital Saint-Louis, Institute of Hematology, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Review
|