Linked Life Data

8800591

Source:http://linkedlifedata.com/resource/pubmed/id/8800591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
1996-11-27
pubmed:abstractText
1. Mutations of the p53 tumour suppressor gene are relatively common in the aetiology of a wide spectrum of tumour types, both sporadic and familial. 2. The majority of mutations of the p53 gene are reported to be in the highly conserved region of exons 5-8. 3. Alterations in exons 4, 5 and 7 of the p53 gene in patients with functional adrenal tumours, including aldosterone-producing adenomas, have recently been described. 4. In the present study PCR-SSCP was used to examine the exons 4-9 of the p53 gene in paired peripheral blood leucocyte and tumour DNA in a variety of adrenal tumours, including aldosterone-producing carcinoma and adenoma (both familial and sporadic), phaeochromocytoma and incidentaloma. 5. No evidence was found for mutations in exons 4-9 of the p53 gene in these varieties of adrenal tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
582-3
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
PCR-SSCP analysis of the p53 gene in tumours of the adrenal gland.
pubmed:affiliation
Hypertension Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.
pubmed:publicationType
Journal Article