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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-10-16
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pubmed:abstractText |
The atypical PKCs are involved in a number of important cellular functions, including cell proliferation. We report here that the product of the par-4 gene specifically interacts with the regulatory domains of zeta PKC and lambda/LPKC, which dramatically inhibits their enzymatic activity. This is particularly challenging, because expression of par-4 has been shown to correlate with growth inhibition and apoptosis. Results are shown here demonstrating that the expression of par-4 in NIH-3T3 cells induces morphological changes typical of apoptosis, which are abrogated by cotransfection of either wild-type zeta PKC or lambda/LPKC, but not by their respective kinase-inactive mutants. These findings support a role for the atypical PKC subspecies in the control of cell growth and survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/LexA protein, Bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mos,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
777-86
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8797824-3T3 Cells,
pubmed-meshheading:8797824-Amino Acid Sequence,
pubmed-meshheading:8797824-Animals,
pubmed-meshheading:8797824-Apoptosis,
pubmed-meshheading:8797824-Apoptosis Regulatory Proteins,
pubmed-meshheading:8797824-Bacterial Proteins,
pubmed-meshheading:8797824-Base Sequence,
pubmed-meshheading:8797824-Carrier Proteins,
pubmed-meshheading:8797824-Cell Line,
pubmed-meshheading:8797824-Cercopithecus aethiops,
pubmed-meshheading:8797824-Cloning, Molecular,
pubmed-meshheading:8797824-Enzyme Inhibitors,
pubmed-meshheading:8797824-Humans,
pubmed-meshheading:8797824-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:8797824-Isoenzymes,
pubmed-meshheading:8797824-Mice,
pubmed-meshheading:8797824-Molecular Sequence Data,
pubmed-meshheading:8797824-Promoter Regions, Genetic,
pubmed-meshheading:8797824-Protein Binding,
pubmed-meshheading:8797824-Protein Kinase C,
pubmed-meshheading:8797824-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8797824-Proto-Oncogene Proteins,
pubmed-meshheading:8797824-Proto-Oncogene Proteins c-mos,
pubmed-meshheading:8797824-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:8797824-Recombinant Fusion Proteins,
pubmed-meshheading:8797824-Sequence Alignment,
pubmed-meshheading:8797824-Sequence Homology, Amino Acid,
pubmed-meshheading:8797824-Serine Endopeptidases,
pubmed-meshheading:8797824-Zinc Fingers
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pubmed:year |
1996
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pubmed:articleTitle |
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.
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pubmed:affiliation |
Centro de Biología Molecular Consejo Superior de Investigaciones Cientificas Universidad Autónoma de Madrid.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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