Linked Life Data

8797727

Source:http://linkedlifedata.com/resource/pubmed/id/8797727

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-10-29
pubmed:abstractText
Human T-cell leukemia/lymphotropic viruses type I and type II (HTLV-I and HTLV-II) are complex human retroviruses showing a similar genetic organization but substantially different biologic and pathogenic properties. As in other complex retroviruses, the 3' portion of the HTLV genome contains the peculiar "X region" comprising several partially overlapping open reading frames (ORFs). To search for a possible basis for the pathogenic differences between the two viruses, a number of studies have been carried out to analyze the coding potential of the X region of HTLV-I and, more recently, of HTLV-II. This review focuses on the coding potential of the HTLV-II X region and presents a comparison with that of HTLV-I. Expression of different ORFs present in the X region may be accessed through two expression strategies: alternative splicing and translation of more than one protein from the same mRNA. Initial analyses of the X region proteins indicate that some differ significantly from their HTLV-I homologues, thus providing possible clues to the understanding of the complex life cycle and pathogenicity of the two viruses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1077-9450
pubmed:author
pubmed:issnType
Print
pubmed:volume
13 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S220-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Coding potential of the X region of human T-cell leukemia/lymphotropic virus type II.
pubmed:affiliation
Institute of Oncology, University of Padova, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't